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2023
Sustainable Development Goals
05 Igualdade de gênero
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LUNG ATELECTASIS PROMOTES IMMUNE AND BARRIER DYSFUNCTION AS REVEALED BY TRANSCRIPTOME SEQUENCING IN FEMALE SHEEP
Zeng, Congli et al. | Date Issued: 2020
Author
Zeng, Congli
Ribeiro, Gabriel C. Motta
Hinoshita, Takuga
Lessa, Marcos Adriano
Winkler, Tilo
Gorgg, Kira
Kingston, Nathan M.
Hutchinson, John N.
Sholl, Lynette Marie
Fang, Xiangming
Varelas, Xaralabos
Layne, Matthew D.
Baron, Rebecca M.
Melo, Marcos F. Vidal
Affilliation
Massachusetts General Hospital. Department of Anesthesia, Critical Care and Pain Medicine. Boston, Massachusetts, USA.
Universidade Federal do Rio de Janeiro. Instituto de Pós-Graduação e Pesquisa em Engenharia. Rio de janeiro, RJ, Brasil.
Tokyo Medical and Dental University. Department of Intensive Care Medicine. Tokyo, Japan.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Massachusetts General Hospital. Department of Anesthesia, Critical Care and Pain Medicine. Boston, Massachusetts, USA.
Massachusetts General Hospital. Department of Radiology. Boston, Massachusetts, USA.
Boston University School of Medicine. Department of Biochemistry. Boston, Massachusetts, USA.
Harvard Chan School of Public Health. Department of Biostatistics. Boston, Massachusetts, USA.
Harvard Medical School. Brigham and Women’s Hospital. Boston, Massachusetts, USA.
Zhejiang University School of Medicine. The First Affiliated Hospital. Department of Anesthesiology. Hangzhou, China.
Boston University School of Medicine. Department of Biochemistry. Boston, Massachusetts, USA.
Boston University School of Medicine. Department of Biochemistry. Boston, Massachusetts, USA.
Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine (Pulmonary and Critical Care). Boston, Massachusetts, USA.
Massachusetts General Hospital. Department of Anesthesia, Critical Care and Pain Medicine Boston, Massachusetts, USA.
Abstract
Pulmonary atelectasis is frequent in clinical settings. Yet there is limited mechanistic understanding and substantial clinical and biologic contro versy on its consequences. The authors hypothesize that atelectasis produces local transcriptomic changes related to immunity and alveolar–capillary barrier function conducive to lung injury and further exacerbated by systemic inflammation.
Keywords in Portuguese
Atelectasia pulmonar
Promove Imune e barreira disfunção
Seqüenciamento de transcriptoma
Ovelhas
 
Keywords
Lung Atelectasis
Promote Barrier Dysfunction
Promote Imune Dysfunction
Female Sheep
Transcriptome Sequencing
 
Publisher
American Society of Anesthesiologists
Citation
ZENG, Congli et al. Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep. Anesthesiology, v. 133, n. 5, 17 p, Nov. 2020.
DOI
10.1097/ALN.0000000000003491
ISSN
1528-1175