| Author | Domitrovic, Tatiana | |
| Author | Moreira, Mariana H. | |
| Author | Carneiro, Rodolfo L. | |
| Author | Ribeiro-Alves, Marcelo | |
| Author | Palhano, Fernando L. | |
| Access date | 2021-12-09T22:05:31Z | |
| Available date | 2021-12-09T22:05:31Z | |
| Document date | 2021 | |
| Citation | DOMITROVIC, Tatiana et al. Natural variation of the cardiac transcriptome in humans. RNA biology, v. 18, n. 10, p. 1374-138, 2021 | pt_BR |
| ISSN | 1547-6286 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50270 | |
| Language | eng | pt_BR |
| Publisher | Taylor & Francis | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Natural variation of the cardiac transcriptome in humans | pt_BR |
| Type | Article | |
| DOI | 10.1080/15476286.2020.1857508 | |
| Abstract | We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features compared to the rest of the genome, such as lower mRNA levels and shorter half-lives coupled to increased translation efficiency. We observed that these genes are mostly involved with immune response and have a pleiotropic effect on disease phenotypes, indicating that asymptomatic conditions contribute to the gene expression diversity of healthy individuals. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Gene expression profiling | pt_BR |
| Subject | Genetic variation | pt_BR |
| Subject | Heart ventricles | pt_BR |
| Subject | Human heart | pt_BR |
| Subject | Ribosome profiling | pt_BR |
| Subject | Translatome | pt_BR |
