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NATURAL VARIATION OF THE CARDIAC TRANSCRIPTOME IN HUMANS
Domitrovic, Tatiana et al. | Date Issued: 2021
Author
Domitrovic, Tatiana
Moreira, Mariana H.
Carneiro, Rodolfo L.
Ribeiro-Alves, Marcelo
Palhano, Fernando L.
Affilliation
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.
Abstract
We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features compared to the rest of the genome, such as lower mRNA levels and shorter half-lives coupled to increased translation efficiency. We observed that these genes are mostly involved with immune response and have a pleiotropic effect on disease phenotypes, indicating that asymptomatic conditions contribute to the gene expression diversity of healthy individuals.
Keywords
Gene expression profiling
Genetic variation
Heart ventricles
Human heart
Ribosome profiling
Translatome
 
Publisher
Taylor & Francis
Citation
DOMITROVIC, Tatiana et al. Natural variation of the cardiac transcriptome in humans. RNA biology, v. 18, n. 10, p. 1374-138, 2021
DOI
10.1080/15476286.2020.1857508
ISSN
1547-6286