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EFFECTIVENESS OF CORONAVAC, CHADOX1, BNT162B2 AND AD26.COV2.S AMONG INDIVIDUALS WITH PRIOR SARS-COV-2 INFECTION IN BRAZIL
COVID-19
CoronaVac
Estudos de casos e controles
Controle de doenças transmissíveis
CoronaVac
ChAdOx1
BNT162b2 and Ad26.COV2.S
Test-negative study
Case-control study
Previous infections
Todos os dados foram pseudo-anônimos com um identificador único comum fornecido pelo Ministério da Saúde do Brasil. O protocolo de pesquisa foi aprovado pela Comissão Nacional de Ética em Pesquisa (CONEP) (número de aprovação 4.921.308).
Author
Silva, Thiago Cerqueira
Andrews, Jason R.
Boaventura, Viviane S.
Ranzani, Otavio T.
Oliveira, Vinicius de Araújo
Paixão, Enny S.
Bertoldo Júnior, Juracy
Machado, Tales Mota
Hitchings, Matt D.T.
Dorion, Murilo
Lind, Margaret L.
Penna, Gerson Oliveira
Cummings, Derek A.T.
Dean, Natalie E.
Werneck, Guilherme Loureiro
Barreto, Maurício Lima
Ko, Albert Icksang
Croda, Julio
Barral Netto, Manoel
Andrews, Jason R.
Boaventura, Viviane S.
Ranzani, Otavio T.
Oliveira, Vinicius de Araújo
Paixão, Enny S.
Bertoldo Júnior, Juracy
Machado, Tales Mota
Hitchings, Matt D.T.
Dorion, Murilo
Lind, Margaret L.
Penna, Gerson Oliveira
Cummings, Derek A.T.
Dean, Natalie E.
Werneck, Guilherme Loureiro
Barreto, Maurício Lima
Ko, Albert Icksang
Croda, Julio
Barral Netto, Manoel
Affilliation
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.
Stanford University. Division of Infectious Diseases and Geographic Medicine. Stanford, CA, United States.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.
ISGlobal. Barcelona Institute for Global Health. Barcelona, Spain / Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Heart Institute. Pulmonary Division. São Paulo, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
London School of Hygiene and Tropical Medicine. London, United Kingdom.
Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Universidade Federal de Ouro Preto. Ouro Preto, MG, Brasil.
University of Florida. College of Public Health & Health Professions. Department of Biostatistics. Gainesville, FL, United States.
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Heaven, CT, United States.
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Heaven, CT, United States.
Universidade de Brasília. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Escola de Governo Fiocruz Brasília. Brasília, DF, Brasil.
University of Florida. Department of Biology. Gainesville, FL, United States / University of Florida. Emerging Pathogens Institute. Gainesville, FL, United States.
Emory University. Rollins School of Public Health. Department of Biostatistics & Bioinformatics. Atlanta, GA, United States.
Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brazil.
London School of Hygiene and Tropical Medicine. London, United Kingdom.
Stanford University. Division of Infectious Diseases and Geographic Medicine. Stanford, CA, United States / Fundação Oswaldo Cruz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Heaven, CT, United States.
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Heaven, CT, United States / Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Stanford University. Division of Infectious Diseases and Geographic Medicine. Stanford, CA, United States.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.
ISGlobal. Barcelona Institute for Global Health. Barcelona, Spain / Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Heart Institute. Pulmonary Division. São Paulo, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
London School of Hygiene and Tropical Medicine. London, United Kingdom.
Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Universidade Federal de Ouro Preto. Ouro Preto, MG, Brasil.
University of Florida. College of Public Health & Health Professions. Department of Biostatistics. Gainesville, FL, United States.
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Heaven, CT, United States.
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Heaven, CT, United States.
Universidade de Brasília. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Escola de Governo Fiocruz Brasília. Brasília, DF, Brasil.
University of Florida. Department of Biology. Gainesville, FL, United States / University of Florida. Emerging Pathogens Institute. Gainesville, FL, United States.
Emory University. Rollins School of Public Health. Department of Biostatistics & Bioinformatics. Atlanta, GA, United States.
Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brazil.
London School of Hygiene and Tropical Medicine. London, United Kingdom.
Stanford University. Division of Infectious Diseases and Geographic Medicine. Stanford, CA, United States / Fundação Oswaldo Cruz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Heaven, CT, United States.
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Heaven, CT, United States / Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Abstract
Background: COVID-19 vaccines have proven highly effective among SARS-CoV-2 naive
individuals, but their effectiveness in preventing symptomatic infection and severe outcomes
among individuals with prior infection is less clear.
Methods: Utilizing national COVID-19 notification, hospitalization, and vaccination datasets
from Brazil, we performed a case-control study using a test-negative design to assess the
effectiveness of four vaccines (CoronaVac, ChAdOx1, Ad26.COV2.S and BNT162b2)
among individuals with laboratory-confirmed prior SARS-CoV-2 infection. We matched RTPCR positive, symptomatic COVID-19 cases with RT-PCR-negative controls presenting with
symptomatic illnesses, restricting both groups to tests performed at least 90 days after an
initial infection. We used multivariable conditional logistic regression to compare the odds of
test positivity, and the odds of hospitalization or death due to COVID-19, according to
vaccination status and time since first or second dose of vaccines.
Findings: Among individuals with prior SARS-CoV-2 infection, vaccine effectiveness
against symptomatic infection ≥ 14 days from vaccine series completion was 39.4% (95% CI
36.1-42.6) for CoronaVac, 56.0% (95% CI 51.4-60.2) for ChAdOx1, 44.0% (95% CI 31.5-
54.2) for Ad26.COV2.S, and 64.8% (95% CI 54.9-72.4) for BNT162b2. For the two-dose
vaccine series (CoronaVac, ChAdOx1, and BNT162b2), effectiveness against symptomatic
infection was significantly greater after the second dose compared with the first dose.
Effectiveness against hospitalization or death ≥ 14 days from vaccine series completion was
81.3% (95% CI 75.3-85.8) for CoronaVac, 89.9% (95% CI 83.5-93.8) for ChAdOx1, 57.7%
(95% CI -2.6-82.5) for Ad26.COV2.S, and 89.7% (95% CI 54.3-97.7) for BNT162b2.
Interpretation. All four vaccines conferred additional protection against symptomatic
infections and severe outcomes among individuals with previous SARS-CoV-2 infection.
Provision of a full vaccine series to individuals following recovery from COVID-19 may
reduce morbidity and mortality.
Keywords in Portuguese
CoronavírusCOVID-19
CoronaVac
Estudos de casos e controles
Controle de doenças transmissíveis
Keywords
COVID-19CoronaVac
ChAdOx1
BNT162b2 and Ad26.COV2.S
Test-negative study
Case-control study
Previous infections
Publisher
Yale University
Citation
CERQUEIRA-SILVA, Thiago et al. Effectiveness of CoronaVac, ChAdOx1, BNT162b2 and Ad26.COV2.S among individuals with prior SARS-CoV-2 infection in Brazil. The BMJ, p. 1-30, 27 Dec. 2021.DOI
10.1101/2021.12.21.21268058Notes
Dados da pesquisa estão no anexo do artigo.Todos os dados foram pseudo-anônimos com um identificador único comum fornecido pelo Ministério da Saúde do Brasil. O protocolo de pesquisa foi aprovado pela Comissão Nacional de Ética em Pesquisa (CONEP) (número de aprovação 4.921.308).
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