Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5510
Title: Worm load and septal fibrosis of the liver in Capillaria hepatica-infected rats.
Authors: Oliveira, Roseli Fernandes
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Inocula, varying from 15 to 1,000 embryonated Capillaria hepatica eggs, were administered to young adult rats by gastric tube, in an attempt to investigate the influence of worm load in the production of septal fibrosis of the liver. Low doses of 15, 30 or 50 eggs were sufficient to produce septal fibrosis, but it appeared with variable degrees of intensity and always with focal distribution. Septal fibrosis became diffuse, progressive with time, and already well developed 40 days after infection, when 100 eggs or more were administered. However, higher inocula (200, 500 and 1,000 eggs) did not intensify septal fibrosis, although the number of parasitic focal lesions proportionally augmented.
Keywords: Capillaria hepatica
Septal hepatic fibrosis
Worm load
DeCS: Capillaria
Infecções por Enoplida/complicações
Cirrose Hepática Experimental/parasitologia
Hepatopatias Parasitárias/parasitologia
Animais
Modelos Animais de Doenças
Feminino
Cirrose Hepática Experimental/patologia
Hepatopatias Parasitárias/patologia
Masculino
Ratos
Ratos Wistar
Issue Date: 2001
Citation: OLIVEIRA, R. F.; ANDRADE, Z. A. Worm load and septal fibrosis of the liver in Capillaria hepatica-infected rats. Memórias do Instituto Oswaldo Cruz, v. 96, n. 7, p. 1001-1003, Oct. 2001.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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