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THE POTENTIAL OF NORAD–PUMILIO–RALGAPB REGULATORY AXIS AS A BIOMARKER IN BREAST CANCER
Proteínas Activadoras de GTPasa
Daño del ADN
Neoplasias de la Mama
Biomarcadores
Proteínas Ativadoras de GTPase
Dano ao DNA
Neoplasias da Mama
Biomarcadores
Author
Affilliation
Abstract
Long non-coding RNAs (LncRNA) represent a heterogeneous family of RNAs that have emerged as regulators of various biological processes through their association with proteins in ribonucleoproteins complexes. The dynamic of these interactions can affect cell metabolism, including cancer development. Annually, breast cancer causes thousands of deaths worldwide, and searching for new biomarkers is pivotal for better diagnosis and treatment. Based on in silico prediction analysis, we focus on LncRNAs that have binding sites for PUMILIO, an RBP family involved in post- transcriptional regulation and associated with cancer progression. We compared the expression levels of these LncRNAs in breast cancer and non-tumor samples from the TCGA database. We analyzed the impact of overall and disease-free survival associated with the expression of the LncRNAs and co-expressed genes and targets of PUMILIO proteins. Our results found NORAD as the most relevant LncRNA with a PUMILIO binding site in breast cancer, differently expressed between Luminal A and Basal subtypes. Additionally, NORAD was co-expressed in a Basal-like subtype (0.55) with the RALGAPB gene, a target gene of PUMILIO related to chromosome stability during cell division. These data suggest that this molecular axis may provide insights for developing novel therapeutic strategies for breast cancer.
Keywords in Spanish
ARN Largo no CodificanteProteínas Activadoras de GTPasa
Daño del ADN
Neoplasias de la Mama
Biomarcadores
DeCS
RNA Longo não CodificanteProteínas Ativadoras de GTPase
Dano ao DNA
Neoplasias da Mama
Biomarcadores
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