Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5646
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dc.contributor.authorFernandez, José Carlos Couto
dc.contributor.authorMorgado, Mariza Gonçalves
dc.contributor.authorBongertz, Vera
dc.contributor.authorTanuri, Amilcar
dc.contributor.authorAndrade, Tarcisio Mattos de
dc.contributor.authorAlves, Carlos Roberto Brites
dc.contributor.authorCastro Filho, Bernardo Galvão
dc.date.accessioned2012-10-04T20:34:19Z
dc.date.available2012-10-04T20:34:19Z
dc.date.issued1999
dc.identifier.citationCOUTO-FERNANDEZ, J.C. et al. HIV-1 subtyping in Salvador, Bahia, Brazil: a city with African sociodemographic characteristics. Journal of Acquired Immune Deficience Syndromes v. 22, n. 3, p. 288-93, nov. 1999.
dc.identifier.issn1525-4135
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/5646
dc.language.isoeng
dc.rightsopen access
dc.titleHIV-1 subtyping in Salvador, Bahia, Brazil: a city with African sociodemographic characteristics
dc.typeArticle
dc.description.abstractenTo investigate the prevalence of the HIV-1 subtypes in different populations from Salvador, Bahia, Brazil, blood samples from 72 HIV-1-seropositive injecting drug users (IDUs) and 62 individuals infected sexually were analyzed using the heteroduplex mobility assay (HMA). In the IDU group, 89.5% were classified as subtype B, 3% as subtype F, and 7.5% showed a B/F HMA profile. In the sexual transmission (ST) group, 95% were identified as B subtype, 3.4% showed a B/F profile, and 1.6% a B/C/E HMA profile. All Brazilian samples that showed multiple reactivities in the HMA analysis clustered on sequencing with B North American/ European HIV-1 isolates in the phylogenetic analysis, whereas the F subtypes clustered with F Brazilian HIV-I isolates. Serologic reactivities of IDU's sera were examined using a panel of synthetic V3 loop peptides representative of the different HIV-1 subtypes. No difference in serologic reactivity between F and B subtype plasma could be observed. Predominance of HIV-I subtype B was identified in both study groups, whereas subtype F was detected only among IDUs in a frequency lower than described for other Brazilian regions.
dc.creator.affilliationFundação Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Departamento de Genética. Rio de Janeiro, RJ, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Centro de Tratamento do Abuso de Drogas. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Laboratorio de Retrovirologia Prof. Edgard Santos Hospital. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.subject.enHIV-1
dc.subject.enSubtypes
dc.subject.enDiversity
dc.subject.enBrazil
dc.subject.decsVariação Antigênica
dc.subject.decsInfecções por HIV/virologia
dc.subject.decsHIV-1/classificação
dc.subject.decsAdolescente
dc.subject.decsAdulto
dc.subject.decsÁfrica/etnologia
dc.subject.decsGrupo com Ancestrais do Continente Africano
dc.subject.decsBrasail
dc.subject.decsEnsaio de Imunoadsorção Enzimática
dc.subject.decsFeminino
dc.subject.decsInfecções por HIV/imunologia
dc.subject.decsInfecções por HIV/transmissão
dc.subject.decsHIV-1/imunologia
dc.subject.decsAnálise Heteroduplex
dc.subject.decsHumanos
dc.subject.decsMasculino
dc.subject.decsMeia-Idade
dc.subject.decsFilogenia
dc.subject.decsReação em Cadeia da Polimerase
dc.subject.decsComportamento Sexual
dc.subject.decsFatores Socioeconômicos
dc.subject.decsAbuso de Substâncias por Via Intravenosa/complicações
Appears in Collections:BA - IGM - Artigos de Periódicos

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