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HUMAN T LYMPHOTROPIC VIRUS TYP7E 1 (HTLV-1) PROVIRAL LOAD IN ASYMPTOMATIC CARRIERS, HTLV-1-ASSOCIATED MYELOPATHY/TROPICAL SPASTIC PARAPARESIS,1 AND OTHER NEUROLOGICAL ABNORMALITIES ASSOCIATED WITH HTLV-1 INFECTION
Silva, Marcus Tulius T. et al. | Date Issued: 2007
Author
Silva, Marcus Tulius T.
Harab, Ramza Cabral
Leite, Ana Cláudia
Schor, Doris
Araújo, Abelardo
Andrada-Serpa, Maria José
Affilliation
Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Reference Center for Neuroinfection Diseases. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratory of Virology. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Reference Center for Neuroinfection Diseases and HTLV. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratory of Virology. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Reference Center for Neuroinfection Diseases and HTLV. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratory of Virology. Reference Center for Neuroinfection Diseases and HTLV. Rio de Janeiro, RJ, Brazil.
Abstract
Recent reports have demonstrated that human T lymphotropic virus type 1 (HTLV-1) is associated with other neurological abnormalities in addition to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been well established that high HTLV-1 proviral loads are associated with the development of HAM/TSP. We now demonstrate, for the first time, to our knowledge, that HTLV-1 proviral loads in patients with other neurological abnormalities are also significantly higher than in asymptomatic HTLV-1 carriers.
Keywords
Human T lymphotropic virus type 1 (HTLV-1)
Asymptomatic Carriers
Neurological Abnormalities
HTLV-1 Infection
 
Publisher
Oxford University Press
Citation
SILVA, Marcus Tulius T. et al. Human T lymphotropic virus type 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis, and other neurological abnormalities associated with HTLV-1 infection. Clinical Infectious Diseases, v. 44, n. 5, p. 689-692, Mar. 2007.
DOI
10.1086/510679
ISSN
1058-4838