Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5814
Title: Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
Authors: Lima, Josilene Borges T
Ribeiro, Guilherme de Sousa
Cordeiro, Soraia Machado
Gouveia, Edilane Lins
Salgado, Kátia M
Spratt, Brian G
Godoy, Daniel
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Reis, Joice Neves
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Secretaria de Saúde do Estado da Bahia. Hospital Couto Maia. Salvador, BA, Brasil
Imperial College London. Department of Infectious Disease Epidemiology. London, UK
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil
Abstract: ince the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, meningitis caused by serotypes other than Hib has gained in importance. We conducted active hospital-based surveillance for meningitis over an 11-year period in Salvador, Brazil. H. influenzae isolates were serotyped and analyzed by polymerase chain reaction, pulsed-field gel electrophoresis, and DNA sequencing to identify strains with a specific deletion (IS1016) in the bexA gene (IS1016-bexA). We identified 43 meningitis cases caused by non-type b H. influenzae: 28 (65%) were caused by type a (Hia), 9 (21%) were caused by noncapsulated strains, and 3 (7%) each were caused by types e and f. Hia isolates clustered in 2 clonal groups; clonal group A strains (n = 9) had the IS1016-bexA deletion. Among children <5 years of age, meningitis caused by Hia from clonal group A had higher case-fatality than meningitis caused by clonal group B. Despite small numbers, these results indicate that the presence of the IS1016-bexA deletion is associated with enhanced virulence in non-type b H. influenzae.
Keywords: Haemophilus influenzae
non-type b H. influenzae
Meningitis
Hib conjugate vaccine
Virulence
IS1016-bexA deletion
Molecular epidemiology
DeCS: Transportadores de Cassetes de Ligação de ATP/genética
Proteínas de Bactérias/genética
Haemophilus/genética
Meningite por Haemophilus
Virulencia/genética
Issue Date: 2010
Citation: LIMA, J. B. et al. Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion. Journal of Infectious Diseases, v. 202, n. 10, p. 1577-1584, nov. 2010.
DOI: 10.1086/656778
ISSN: 1537-6613
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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