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ANTITUMOR EFFECT OF AÇAÍ (EUTERPE OLERACEA MART.) SEED EXTRACT IN LNCAP CELLS AND IN THE SOLID EHRLICH CARCINOMA MODEL
Imunoproteção
Açaí
Euterpe oleracea
Modelo de mouse
Atividade antitumoral
Author
Affilliation
Abstract
Abstract: Euterpe oleracea (açaí) fruit has approximately 15% pulp, which is partly edible and commercialized,
and 85% seeds. Although açaí seeds are rich in catechins—polyphenolic compounds
with antioxidant, anti-inflammatory, and antitumor effects—almost 935,000 tons/year of seeds are
discarded as industrial waste. This work evaluated the antitumor properties of E. oleracea in vitro and
in vivo in a solid Ehrlich tumor in mice. The seed extract presented 86.26 0.189 mg of catechin/g of
extract. The palm and pulp extracts did not exhibit in vitro antitumor activity, while the fruit and seed
extracts showed cytotoxic effects on the LNCaP prostate cancer cell line, inducing mitochondrial and
nuclear alterations. Oral treatments were performed daily at 100, 200, and 400 mg/kg of E. oleracea
seed extract. The tumor development and histology were evaluated, along with immunological and
toxicological parameters. Treatment at 400 mg/kg reduced the tumor size, nuclear pleomorphism,
and mitosis figures, increasing tumor necrosis. Treated groups showed cellularity of lymphoid organs
comparable to the untreated group, suggesting less infiltration in the lymph node and spleen and preservation of the bone marrow. The highest doses reduced IL-6 and induced IFN-
suggesting antitumor and immunomodulatory effects. Thus, açaí seeds can be an important source of compounds
with antitumor and immunoprotective properties.
Keywords in Portuguese
CâncerImunoproteção
Açaí
Euterpe oleracea
Modelo de mouse
Atividade antitumoral
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