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2030-12-31
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DETECTION OF HCV RNA IN SALIVA DOES NOT CORRELATE WITH SALIVARY FLOW OR XEROSTOMIA IN PATIENTS WITH CHRONIC HEPATITIS C
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Universidade Federal de Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. School of Medicine. Department of Internal Medicine. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. School of Medicine. Department of Internal Medicine. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology. Belo Horizonte, MG, Brazil
Abstract
Objective. The objective of this study was to investigate the prevalence of hepatitis C virus (HCV) RNA in saliva and its possible association with xerostomia and hyposalivation in patients with chronic hepatitis C. Study design. One hundred and thirty-six patients with confirmed diagnosis of chronic hepatitis C were prospectively analyzed before HCV treatment. The prevalence of xerostomia and hyposalivation was clinically evaluated. HCV RNA was investigated in saliva samples by qualitative PCR test. Univariate and multivariate analyses were used to verify associations. Results. Xerostomia was reported by 48 (35.3%) patients, whereas hyposalivation was observed in 26 (19.1%). HCV RNA was positive in the saliva of 53 (39.0%) patients. An association among HCV RNA-positive saliva with xerostomia or hyposalivation was not observed. Conclusion. Our results demonstrate that the detection of HCV in saliva does not correlate with salivary flow or xerostomia in patients with chronic hepatitis C. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: 851-856
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