Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7127
Title: Synergistic associations between hookworm and other helminth species in a rural community in BrazilSynergistic associations between hookworm and other helminth species in a rural community in Brazil
Authors: Fleming, Fiona M.
Brooker, Simon
Geiger, Stefan Michael
Caldas, Iramaya Rodrigues
Oliveira, Rodrigo Correa de
Hotez, Peter J.
Bethony, Jeffrey Michael
Affilliation: London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases. London, UK/ Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases. London, UK
Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil/The George Washington University. Department of Microbiology and Tropical Medicine Washington DC, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
George Washington University. Department of Microbiology and Tropical Medicine Washington DC, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil/George Washington University. Department of Microbiology and Tropical Medicine Washington DC, USA
Abstract: Objective  To identify possible synergistic associations of hookworm and other helminths. Method  Cross-sectional survey of all households within 10 km2 of Americaninhas, a rural community in Minas Gerais, Brazil. We determined the prevalence and intensity of single and multiple helminth species infection in an age-stratified sample of 1332 individuals from 335 households. Results  Hookworm was the most prevalent helminth infection (68.2%), followed by Ascaris lumbricoides (48.8%) and Schistosoma mansoni (45.3%). Overall, 60.6% of individuals harboured mixed helminth infections. Multivariate analysis indicated significant positive associations for co-infection with hookworm and S. mansoni and for co-infection with hookworm and A. lumbricoides. Co-infections with hookworm and A. lumbricoides resulted in higher egg counts for both, suggesting a synergistic relationship between these species, although, we found important age differences in this relationship. However, the intensity of S. mansoni or A. lumbricoides co-infection did not differ from that of mono-infection. Conclusion  These results have implications for the epidemiology, immunology and control of multiple helminth infections. More research is needed to examine the rates of re-infection and immune responses after chemotherapy, and to what extent the effects of polyparasitism are altered by chemotherapy.
Keywords: hookworm
Ascaris lumbricoides
Schistosoma mansoni
epidemiology
polyparasitism
Brazil
Issue Date: 2006
Publisher: Blackwell Publishing
Citation: FLEMING, Fiona M. et al. Synergistic associations between hookworm and other helminth species in a rural community in Brazil. Tropical Medicine & International Health. 2006; 11(1): 56-64
DOI: 10.1111/j.1365-3156.2005.01541.x
ISSN: 1365-3156
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos

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