Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7612
Title: Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice
Authors: Almeida, Roque Pacheco de
Barral Netto, Manoel
Jesus, Amélia Maria Ribeiro de
Freitas, Luiz Antonio Rodrigues de
Carvalho Filho, Edgar Marcelino
Barral, Aldina Maria Prado
Affilliation: Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil
Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil
Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil
Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil
Abstract: Leishmania amazonensis causes a wide spectrum of disease in humans. In this study, we evaluated BALB/c mice infected with five strains of L. amazonensis isolated from patients with either cutaneous, mucosal, or visceral leishmaniasis. Mice infected with cutaneous and mucosal isolates developed ulcerating footpad lesions with parasite-loaded macrophages and extensive tissue destruction. Skin métastases,early dissemination of parasites to the spleen, and high anü-Leishmaniaantibody levels were also noted. Mice infected with L. amazonensis strains isolated from patients with visceral disease had a controlled infection, with small footpad lesions with mononuclear cell infiltration, few infected macrophages, and granuloma formation. They had no skin métastases,delayed dissemination of the parasite to the spleen, lower levels of IgG and higher levels of IgG2a against L. amazonensis. These findings demonstrate an unexpected resistance of BALB/c mice to the infection with L. amazonensis isolated from patients with visceral leishmaniasis. This resistance seems to be due to differences in these parasites that may be related to the altered course of the disease in humans and in isogenic BALB/c mice.
DeCS: Leishmania/patogenicidade
Leishmaniose Cutânea/parasitologia
Leishmaniose Mucocutânea/parasitologia
Leishmaniose Visceral/parasitologia
Animais
Anticorpos Antiprotozoários/sangue
Feminino
Humanos
Imunoglobulina G/sangue
Leishmania/imunologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Issue Date: 1996
Publisher: American Society of Tropical Medicine and Hygiene
Citation: ALMEIDA, R. P. et al. Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice. American Journal of Tropical Medicine and Hygiene, v. 54, n. 2, p. 178-184, 1996.
ISSN: 0002-9637
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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