Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7952
Title: Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.
Authors: Seixas, Magda Oliveira
Rocha, Larissa Carneiro
Carvalho, Mauricio Barreto
Menezes, Joelma Figueiredo
Lyra, Isa Menezes
Nascimento, Valma Maria Lopes do
Couto, Ricardo David
Atta, Ajax Mercês
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. 2Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil
Fundação de Hematologia e Hemoterapia da Bahia. HEMOBA. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Pediátrico Professor Hosannah de Oliveira. Salvador, BA, Brasil
Fundação de Hematologia e Hemoterapia do Estado da Bahia. HEMOBA. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil
Abstract: BACKGROUND: The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up. We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C) in steady-state children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, anti-aggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis. METHODS: We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counter respectively. Clinical data were collected from patient medical records. RESULTS: Of the 152 infants investigated had a significant positive association of high-density lipoprotein cholesterol with hemoglobin (P < 0.001), hematocrit (P < 0.001) and total cholesterol (P < 0.001) and a negative significant association with reticulocytes (P = 0.046), leukocytes (P = 0.015), monocytes (P = 0.004) and platelets (P = 0.005), bilirubins [total bilirubin (P < 0.001), direct bilirubin (P < 0.001) and indirect bilirubin (P < 0.001], iron (P < 0.001), aminotransferases [aspartate aminotransferase (P = 0.004), alanine aminotransferase (P = 0.035)], lactate dehydrogenase (P < 0.001), urea (P = 0.030), alpha 1-antitrypsin (P < 0.001), very low-density lipoprotein cholesterol (P = 0.003), triglycerides (P = 0.005) and hemoglobin S (P = 0.002). Low high-density lipoprotein cholesterol concentration was associated with the history of cardiac abnormalities (P = 0.025), pneumonia (P = 0.033) and blood transfusion use (P = 0.025). Lipids and inflammatory markers were associated with the presence of cholelithiasis. CONCLUSIONS: We hypothesize that some SCD patients can have a specific dyslipidemic subphenotype characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers, including those related to inflammation. This represents an important step toward a more reliable clinical prognosis. Additional studies are warranted to test this hypothesis and the probably mechanisms involved in this complex network of markers and their role in SCD pathogenesis
DeCS: Anemia Falciforme/sangue
Anemia Falciforme/fisiopatologia
HDL-Colesterol/sangue
Dislipidemias/sangue
Adolescente
Anemia Falciforme/complicações
Marcadores Biológicos/sangue
Brasil/epidemiologia
Criança
Colelitíase/complicações
Colelitíase/epidemiologia
Dislipidemias/epidemiologia
Feminino
Cardiopatias Congênitas/complicações
Hemólise
Mediadores da Inflamação/sangue
Humanos
Lipídeos/sangue
Masculino
Registros Médicos
Pneumonia/complicações
Prevalência
Prognóstico
Issue Date: 2010
Publisher: BioMed Central
Citation: SEIXAS, M. O. et al. Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease. Lipids in Health and Disease, v. 9, p. 91, 2010.
DOI: 10.1186/1476-511X-9-91
ISSN: 1476-511X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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