Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8136
Title: HTLV-I in the general population of Salvador, Brazil: a city with African ethnic and sociodemographic characteristics.
Authors: Dourado, Inês
Alcantara, Luiz Carlos Júnior
Barreto, Maurício Lima
Teixeira, Maria da Glória
Castro Filho, Bernardo Galvão
Affilliation: Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para Desenvolvimento das Ciências. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para Desenvolvimento das Ciências. Salvador, BA, Brasil
Abstract: The city of Salvador has the highest prevalence of HTLV-I among blood donors in Brazil. To study the prevalence of HTLV-I among the general population of Salvador, 30 “sentinel surveillance areas” were selected for the investigation of various infectious diseases, and 1385 individuals within these areas were surveyed according to a simple random sample procedure. ELISA was used to screen plasma samples for antibodies to HTLV-I, and the positive samples were tested by a confirmatory assay (Western blotting). The overall prevalence of HTLV-I was 1.76% (23/1385). Infection rates were 1.2% for males and 2.0% for females. Specific prevalence demonstrated an increasing linear trend with age. No one younger than 13 years of age was infected. Multivariate analysis estimated adjusted odds ratios for the association of HTLV-I with age of 9.7 (3.3; 30.4) for females and 12.3 (1.47; 103.1) for males. Less education and income might be associated with HTLV-I infection in females. Phylogenetic analysis of the long terminal repeat fragments showed that most of the samples belonged to the Latin American cluster of the Transcontinental subgroup (Cosmopolitan subtype). For the entire city of Salvador, it is estimated that ∼40,000 individuals are infected with HTLV-I. Our results suggest multiple post-Colombian introductions of African HTLV-Ia strains in Salvador.
DeCS: Infecções por HTLV-I/epidemiologia
Adolescente
Adulto
África/etnologia
Doadores de Sangue
Brasil/epidemiologia
Criança
Demografia
Escolaridade
Ensaio de Imunoadsorção Enzimática
Feminino
Soroprevalência de HIV
Anticorpos Anti-HTLV-I/sangue
Infecções por HTLV-I/diagnóstico
Humanos
Renda
Masculino
Meia-Idade
Prevalência
Fatores Socioeconômicos
População Urbana
Issue Date: 2003
Publisher: Lippincott Williams & Wilkins
Citation: DOURADO, I. et al. HTLV-I in the general population of Salvador, Brazil: a city with African ethnic and sociodemographic characteristics. Journal of Acquired Immune Deficiency Syndromes, v. 34, n. 5, p. 527-531, 2003.
ISSN: 1525-4135
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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