Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8486
Title: Microbiology of the middle meatus compared to sputum in young patients with cystic fibrosis from Bahia - Brazil.
Authors: Tunes, Alessandro
Reis, Joice Neves
Terse, Regina
Santana, Maria Angélica
Diniz, Ana Lúcia
Barros, Tania Fraga
Leal, Ana Karina Souza
Paixão, Vilma
Grassi, Maria Fernanda Rios
Affilliation: Postgraduate Course in Medicine and Human Health of Bahian School of Medicine and Public Health. Salvador, BA, Brasil / Federal University of Bahia. Microbiological Laboratory. School of Pharmacy. Salvador, BA, Brasil
Federal University of Bahia. Microbiological Laboratory. School of Pharmacy. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Postgraduate Course in Medicine and Human Health of Bahian School of Medicine and Public Health. Salvador, BA, Brasil / Octávio Mangabeira Hospital. BrazilcPediatric Pulmonary Clinic of Bahia Reference Center for Cystic Fibrosis. Salvador, BA, Brasil
Octávio Mangabeira Hospital. Pediatric Pulmonary Clinic of Bahia Reference Center for Cystic Fibrosis. Salvador, BA, Brasil
Octávio Mangabeira Hospital. Pediatric Pulmonary Clinic of Bahia Reference Center for Cystic Fibrosis. Salvador, BA, Brasil
Federal University of Bahia. Microbiological Laboratory. School of Pharmacy. Salvador, BA, Brasil
Federal University of Bahia. Microbiological Laboratory. School of Pharmacy. Salvador, BA, Brasil
Octávio Mangabeira Hospital. Microbiological Laboratory. Salvador, BA, Brasil
Postgraduate Course in Medicine and Human Health of Bahian School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Lower airway infection is a major cause of morbidity and mortality in patients with cystic fibrosis. It is currently unknown if the infection of the upper airway can cause exacerbation of lower respiratory tract infection. This study aimed to determine the microbiological profile of the anterior paranasal sinuses outflow tract (middle meatus) of cystic fibrosis outpatients. The microbiological profile was defined using endoscopically directed middle meatal cultures. Paired middle meatal and sputum specimens were collected from 56 outpatients for aerobic cultures. A semi-quantitative leukocyte count of the middle meatal samples was performed. The median age of patients was nine years (3-20 years). Staphylococcus aureus (37%), Staphylococcus coagulase-negative (25%), Neisseriac (14%), Pseudomonas aeruginosa (11%), and Streptococcus pneumoniae (7%) were the most prevalent microorganisms in the middle meatal cultures. Using the middle meatal leukocyte count, 16 out of 54 patients (29.6%) presented sinus infection. The most frequently identified pathogens in patients with sinus infections were Staphylococcus aureus (10 patients), Pseudomonas aeruginosa (4 patients), and Streptococcus pneumoniae (3 patients). Agreement of paired middle meatal and sputum cultures was significantly higher among patients with infection in middle meatal (69%). The most common middle meatal pathogens were the typical cystic fibrosis spectrum. This suggests the potential for participating in post-nasal lower airway seeding
Keywords: Cystic fibrosis
Middle meatus
Infection
Endoscopy
DeCS: Fibrose Cística/microbiologia
Bactérias Gram-Negativas/isolamento & purificação
Bactérias Gram-Positivas/isolamento & purificação
Seios Paranasais/microbiologia
Escarro/microbiologia
Adolescente
Brasil
Criança
Pré-Escolar
Feminino
Humanos
Masculino
Estudos Prospectivos
Adulto Jovem
Issue Date: 2013
Publisher: Elsevier Editora Ltda
Citation: TUNES, A. et al. Microbiology of the middle meatus compared to sputum in young patients with cystic fibrosis from Bahia - Brazil. Brazilian Journal of Infectious Diseases, v. 18, n. 2, p. 215-219, 2014.
DOI: 10.1016/j.bjid.2013.07.006
ISSN: 1678-4391
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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