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CYTOTOXIC EFFECT OF LEAF ESSENTIAL OIL OF LIPPIA GRACILIS SCHAUER (VERBENACEAE).
Lippia/química
Óleos Voláteis/farmacologia
Alcenos/farmacologia
Animais
Brasil
Linhagem Celular Tumoral/efeitos de drogas
Membrana Celular/efeitos de drogas
Cromatografia Gasosa-Espectrometria de Massas
Células Hep G2/efeitos de drogas
Humanos
Masculino
Camundongos
Monoterpenos/farmacologia
Óleos Voláteis/análise
Folhas de Planta/química
Plantas Medicinais/química
Autor(es)
Afiliação
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Biology. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Biology. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Biology. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Biology. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brasil
Resumo em Inglês
Medicinal plants are one of the most important sources of drugs used in the pharmaceutical industry.
Among traditional medicinal plants, Lippia gracilis Schauer (Verbenaceae) had been used for several
medicinal purposes in Brazilian northeastern. In this study, leaf essential oil (EO) of L. gracilis was prepared
using hydrodistillation. Followed by GC–MS analysis, its composition was characterized by the
presence of thymol (55.50%), as major constituent. The effects of EO on cell proliferation and apoptosis
induction were investigated in HepG2 cells. Furthermore, mice bearing Sarcoma 180 tumor cells were
used to confirm its in vivo effectiveness. EO and its constituents (thymol, p-cymene, -terpinene and
myrcene) displayed cytotoxicity to different tumor cell lines. EO treatment caused G1 arrest in HepG2
cells accompanied by the induction of DNA fragmentation without affecting cell membrane integrity.
Cell morphology consistent with apoptosis and a remarkable activation of caspase-3 were also observed,
suggesting induction of caspase-dependent apoptotic cell death. In vivo antitumor study showed tumor
growth inhibition rates of 38.5–41.9%. In conclusion, the tested essential oil of L. gracilis leaves, which
has thymol as its major constituent, possesses significant in vitro and in vivo antitumor activity. These
data suggest that leaf essential oil of L. gracilis is a potential medicinal resource.
DeCS
Antineoplásicos Fitogênicos/farmacologiaLippia/química
Óleos Voláteis/farmacologia
Alcenos/farmacologia
Animais
Brasil
Linhagem Celular Tumoral/efeitos de drogas
Membrana Celular/efeitos de drogas
Cromatografia Gasosa-Espectrometria de Massas
Células Hep G2/efeitos de drogas
Humanos
Masculino
Camundongos
Monoterpenos/farmacologia
Óleos Voláteis/análise
Folhas de Planta/química
Plantas Medicinais/química
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