Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8929
Title: Antibodies against Lutzomyia longipalpis saliva in the fox Cerdocyon thous and the sylvatic cycle of Leishmania chagasi
Authors: Gomes, Regis Bernardo Brandim
Mendonça, Ivete Lopes de
Silva, Vladimir Costa
Ruas, Jerônimo Lopes
Silva, Mauro Roberto Biá da
Cruz, Maria do Socorro Pires
Barral, Aldina Maria Prado
Costa, Carlos Henrique Nery
Affilliation: Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, Brasil
Universidade Federal do Piauí. Laboratório de Sanidade Animal. LASAN. Teresina, PI, Brasil
Universidade Federal do Piauí. Instituto de Doenças Tropicais Natan Portella. Laboratório de Leishmanioses. Teresina, PI, Brasil
Universidade Federal de Pelotas. Faculdade de Veterinária. Pelotas, RS, Brasil
Universidade Federal do Piauí. Instituto de Doenças Tropicais Natan Portella. Laboratório de Leishmanioses. Teresina, PI, Brasil
Universidade Federal do Piauí. Instituto de Doenças Tropicais Natan Portella. Laboratório de Leishmanioses. Teresina, PI, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, Brasil
Universidade Federal do Piauí. Instituto de Doenças Tropicais Natan Portella. Laboratório de Leishmanioses. Teresina, PI, Brasil
Abstract: Sera of 11 wild Cerdocyon thous foxes from an endemic area for American visceral leishmaniasis were tested for the presence of antibodies against salivary gland homogenates (SGH) of Lutzomyia longipalpis. All foxes had higher levels of anti-Lu. longipalpis SGH antibodies than foxes from non-endemic areas, suggesting contact between foxes and the vector of visceral leishmaniasis. Sera of humans and dogs living in the same area were also tested for reactivity against Lu. longipalpis SGHs and had a lower proportion of reactivity than foxes. Antibodies against Leishmania chagasi were not detected in any of the foxes, but three foxes showed the presence of parasites in the bone marrow by direct examination, PCR or by infecting the vector. Both humans and dogs had higher levels of anti-Le. chagasi IgG antibodies than C. thous. The finding of an antibody response against saliva of Lu. longipalpis among C. thous together with the broad distribution of the vector in resting areas of infected foxes suggests that the natural foci of transmission of Le. chagasi exists independently of the transmission among dogs and humans.
Keywords: Leishmania chagasi
Lutzomyia longipalpis
Cerdocyon thous
Antibody
Saliva
Brasil
DeCS: Anticorpos Antiprotozoários/sangue
Raposas/parasitologia
Leishmania infantum/imunologia
Psychodidae/imunologia
Saliva/parasitologia
Animais
Western Blotting
Medula Óssea/parasitologia
Cães
Ensaio de Imunoadsorção Enzimática
Humanos
Imunidade Celular
Camundongos
Reação em Cadeia da Polimerase/métodos
Saliva/imunologia
Glândulas Salivares/parasitologia
Issue Date: 2007
Publisher: Elsevier Ltd
Citation: GOMES, R. B. B. et al. Antibodies against Lutzomyia longipalpis saliva in the fox Cerdocyon thous and the sylvatic cycle of Leishmania chagasi. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 101, n. 2, p. 127-133, 2007.
DOI: 10.1016/j.trstmh.2006.06.002
ISSN: 0035-9203
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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