PorA Variable Antigenic Regions VR1, VR2, and VR3 of Neisseria meningitidis Serogroups B and C Isolated in Brazil from 1999 to 2004

Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.
National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Infectious Diseases. Bethesda, MD, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.

Abstract

The high genetic diversity found among the PorA regions VR1 and VR2 of 101Neisseria meningitisdis isolates from patients with meningococcal disease and healthy carriers in Brazil contrasts with the stability found in the PorA VR3 of these isolates. The presence of VR3 epitope variant 35 or 36 on the surfaces of 87% of the strains analyzed suggests that these antigens should be considered for inclusion in new formulations of vaccines against serogroup B meningococci in Brazil.

Publisher

American Society for Microbiology

Citation

FILIPPIS, I. et al. PorA Variable Antigenic Regions VR1, VR2, and VR3 of Neisseria meningitidis Serogroups B and C Isolated in Brazil from 1999 to 2004. Infect Immun., v. 75, n. 7, p. 3683-3685, 2007.

DOI

http://dx.doi.org/10.1128/iai.01721-06

ISSN

0019-9567

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/13062

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