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MOLECULAR EPIDEMIOLOGY OF NEISSERIA MENINGITIDIS SEROGROUP B IN BRAZIL
Filippis, Ivano de et al. | Date Issued: 2012
Author
Filippis, Ivano de
Lemos, Ana Paula Silva de
Hostetler, Jessica B.
Wollenberg, Kurt
Sacchi, Claudio T.
Dunning Hotopp, Julie C.
Harrison, Lee H.
Bash, Margaret C.
Prevots, D. Rebecca
Affilliation
Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil.
Instituto Adolfo Lutz, Departamento de Bacteriologia. São Paulo, SP, Brasil.
J. Craig Venter Institute. Maryland, USA.
National Institute of Allergy and Infectious Diseases, National Institutes of Health. Maryland, USA.
Instituto Adolfo Lutz, Departamento de Imunologia. São Paulo, SP, Brasil.
University of Pittsburgh. Pennsylvania, USA.
Food and Drug Administration. Maryland, USA.
National Institute of Allergy and Infectious Diseases, National Institutes of Health. Maryland, USA.
Abstract
Neisseria meningitidis serogroup B has been predominant in Brazil, but no broadly effective vaccine is available to prevent endemic meningococcal disease. To understand genetic diversity among serogroup B strains in Brazil, we selected a nationally representative sample of clinical disease isolates from 2004, and a temporally representative sample for the state of São Paulo (1988-2006) for study (n = 372).
Keywords
Bacterial Typing Techniques
Base Sequence
Biodiversity
Genes, Bacterial
Genetic Variation
Likelihood Functions
Meningococcal Infections
Molecular Epidemiology
Molecular Sequence Data
Multilocus Sequence Typing
Neisseria meningitidis, Serogroup B
Phylogeny
Time Factors
 
DeCS
Técnicas de Tipagem Bacteriana
Sequência de Bases
Biodiversidade
Genes Bacterianos
Variação Genética
Funções Verossimilhança
Infecções Meningocócicas
Epídemiologia Molecular
Dados de Sequência Molecular
Tipagem de Sequências Multilocus
Neisseria meningitidis Sorogrupo B
Filogenia
Fatores de Tempo
 
Citation
FILIPPIS, I. et al. Molecular epidemiology of Neisseria meningitidis serogroup B in Brazil. PLoS One, v. 7, n. 3, p. e33016, 2012.
DOI
http://dx.doi.org/10.1371/journal.pone.0033016
ISSN
1932-6203
Notes
PLoS One. 2012;7(7): doi/10.1371/annotation/6318254d-3f13-4cca-8bbe-08d0ff29aa64. Dunning Hotopp, Julie C [adicionado].