E-cadherin regulators are differentially expressed in the epithelium and stroma of keratocystic odontogenic tumors

Federal University of Bahia. School of Dentistry. Pos-graduate of Dentistry and Health. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Department of Propaedeutics and Integrated Clinical Practicum. Surgical Pathology Laboratory. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Department of Propaedeutics and Integrated Clinical Practicum. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Department of Social and Pediatric Dentistry. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Pos-graduate of Dentistry and Health. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Department of Propaedeutics and Integrated Clinical Practicum. Salvador, BA, Brazil
University of São Paulo. Institute of Biomedical Sciences. Department of Anatomy, Extracellular Matrix Biology and Cellular Interaction Laboratory. São Paulo, SP, Brazil
Federal University of Bahia. School of Dentistry. Department of Propaedeutics and Integrated Clinical Practicum. Surgical Pathology Laboratory. Salvador, BA, Brazil

Abstract

The epithelial-mesenchymal transition (EMT) is the process where cells lose their epithelial features and acquire properties of typical mesenchymal cells. The dissociation of tumor cells due to changes in cell-cell adhesion is one of the key principles of tumor invasion and EMT. Thus, the knowledge of the molecular features of EMT in keratocyst odontogenic tumor (KOT) can provide useful markers to aid in the diagnosis and prognosis and perhaps contribute to an alternative therapeutic approach as it shows an aggressive clinical behavior and high recurrence rates. This study aimed to evaluate the EMT in KOT by the immunoexpression of E-cadherin, N-cadherin, Snail, and Slug and comparing to radicular cysts and dental follicles.

Keywords in Portuguese

Adesão celular
E-caderina
Transição epitelial-mesenquimal
Imuno-histoquímica
Tumores odontogênicos

Keywords

Cell adhesion
E-cadherin
Epithelial–mesenchymal transition
Immunohistochemistry
Odontogenic tumors

Publisher

Wiley

Citation

PORTO, L. P. A. et al. E-cadherin regulators are differentially expressed in the epithelium and stroma of keratocystic odontogenic tumors. Journal of Oral Pathology & Medicine, v. 45, p. 302–311, 2016.

DOI

10.1111/jop.12382

ISSN

0904-2512

Notes

Gurgel, Clarissa Araújo. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25532

Type

Copyright

Open access

Sustainable Development Goals

Collections

Share

Statistics

Metadata

Author

Affilliation