Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31405
Title: Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort
Authors: Rocha, Aline dos Santos
Silva, Rita de Cássia Ribeiro
Costa, Gustavo Nunes de Oliveira
Figueiredo, Camila Alexandrina
Rodrigues, Laura Cunha
Matos, Sheila Maria Alvim
Fiaccone, Rosemeire Leovigildo
Oliveira, Pablo Rafael
Santos, Nadya Helena Alves
Blanton, Ronald Edward
Barreto, Maurício Lima
Affilliation: Universidade Federal da Bahia. Escola de Nutrição. Departamento Ciência da Nutrição. Salvador, BA, Brasil.
Universidade Federal da Bahia. Escola de Nutrição. Departamento Ciência da Nutrição. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Salvador. Laureate International Universities. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biorregulação. Salvador, BA, Brasil.
London School of Hygiene and Tropical Medicine. Department of Epidemiology and Population Health. London, WC.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Observatório de Epidemiologia Nutricional. Departamento de Nutrição Aplicada e Social. Rio de Janeiro, RJ, Brasil.
Case Western Reserve University. Center for Global Health & Diseases. Biomedical Research Building. Cleveland, OH, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Abstract: No studies showing that food consumption is a modifier of the association of variants of the leptin receptor gene (LEPR) with body weight have involved a Brazilian population. The aim of this study was to evaluate the modifying effect of dietary intake on the association between the LEPR gene and excess weight. In this study, 1211 children and adolescents aged 4⁻11 years were assessed. Participants were genotyped for 112 single-nucleotide variants of the LEPR gene. Anthropometric measurements were performed, and dietary data were obtained. Logistic regressions were used to study the associations of interest. Of the participants, 13.4% were overweight/obese. The risk allele (G) of the rs1137100 variant was associated with excess weight in individuals with fat consumption below the median (odds ratio OR = 1.92; 95% confidence interval CI = 1.18⁻3.14), with daily frequency of consumption of drink/artificial juice (OR = 2.15; 95% CI = 1.26⁻3.68) and refined cereals (OR = 2.17; 95% CI = 1.31⁻3.62) above the median. The risk allele (G) of variant rs1177681 was also associated with excess weight (OR = 2.74; 95% CI = 1.65⁻4.57) in subjects with a daily frequency of refined cereal consumption above the median. The association between LEPR and excess weight can be modulated by the type and distribution of dietary fatty acids, sugary drinks, and refined cereals.
Keywords: Overweight
Obesity
Leptin receptor gene
Children and adolescents
Food consumption
keywords: Excesso de peso
Obesidade
Gene do receptor da leptina
Crianças e adolescentes
Consumo de comida
Issue Date: 2018
Publisher: MDPI
Citation: ROCHA, A. S. et al. Food consumption as a modifier of the Association between LEPR gene variants and excess body weight in children and adolescents: A study of the SCAALA Cohort. Nutrients, v. 10, p. 1-14, 2018.
DOI: 10.3390/nu10081117
ISSN: 2072-6643
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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