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LYMPHOCYTE-DEPENDENT AND TH2 CYTOKINE-ASSOCIATED COLITIS IN MICE DEFICIENT IN WISKOTT-ALDRICH SYNDROME PROTEIN
Nguyen, Deanna D. et al. | Date Issued: 2007
Author
Nguyen, Deanna D.
Maillard, Michel H.
Almeida, Vinicius Cotta de
Mizoguchi, Emiko
Klein, Christoph
Fuss, Ivan
Nagler, Cathryn
Mizoguchi, Atsushi
Bhan, Atul K.
Snapper, Scott B.
Affilliation
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA / Lausanne Medical School. Department of Medicine Division of Gastroenterology and Hepatology. Lausanne, Switzerland.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.
Hannover Medical School. Department of Pediatric Hematology/Oncology. Hannover, Germany.
National Institute of Health. Mucosal Immunity Section. Bethesda, Maryland, USA.
Massachusetts General Hospital. Center for the Study of Inflammatory Bowel Diseases. Division of Rheumatology, Allergy and Immunology. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.
Massachusetts General Hospital. Immunopathology Unit. Boston, MA, USA / Harvard Medical School. Department of Pathology. Boston, MA, USA.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Pathology. Boston, MA, USA.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.
Abstract
Controversy exists as to whether patients with inflammatory bowel disease have an underlying immunodeficiency. We have focused on a murine model of the Wiskott-Aldrich syndrome, an immunodeficiency in which autoimmunity can manifest in the form of an inflammatory bowel disease-like illness. Wiskott-Aldrich syndrome protein (WASP) deficiency in mice results in similar clinical features. Herein, we characterized the colitis in WASP-deficient mice.
Keywords in Portuguese
Síndrome de Wiskott-Aldrich
Colite
Linfócitos
Citocinas Th2
Ratos deficientes
 
Keywords
Wiskott-Aldrich Syndrome Protein
Colitis
Lymphocyte
Th2 Cytokine
Mice Deficient
 
Publisher
Elsevier: 12 months
Citation
NGUYEN, Deanna D. et al. Lymphocyte-Dependent and Th2 Cytokine-Associated Colitis in Mice Deficient in Wiskott-Aldrich Syndrome Protein. Gastroenterology, v. 133, n. 4, p. 1188-1197, Oct. 2007.
DOI
10.1053/j.gastro.2007.07.010
ISSN
0016-5085