Browsing by Subject "Relação Estrutura-Atividade"

2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation.

Cardoso, Marcos Veríssimo de Oliveira et al. | Date Issued: 2014

Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents

Santos Filho, José Maurício dos et al. | Date Issued: 2009

ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation.

Dutra, Lívia Macedo et al. | Date Issued: 2014

Imunologia aplicada ao desenvolvimento de novas estratégias de controle para as leishmanioses: uma abordagem terapêutica em leishmaniose tegumentar americana

Melo, Maria Gabriella Nunes de. | Date Issued: 2022

O objetivo deste estudo é avaliar o potencial imunomodulador de novas estratégias terapêuticas para Leishmaniose tegumentar americana (LTA). Os compostos ftalimídicos-triazólicos (RN1, RN2 e RN3) e o extrato bruto da ...

In silico and in vitro: identifying new drugs

Pauli, Ivani et al. | Date Issued: 2008

New imidazolidine derivatives as anti-Trypanosoma cruzi agents: structure-activity relationships

Gomes, Fabiana Oliveira dos Santos et al. | Date Issued: 2012

Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice.

Santos Filho, José Maurício dos et al. | Date Issued: 2012

Proposição de modelos tridimensionais da extensão COOH-terminal da cisteíno-protease B de Leishmania (Leishmania) amazonensis

Santos, Deborah Antunes dos | Date Issued: 2014

A Leishmania (Leishmania) amazonensis é um importante agente etiológico da leishmaniose tegumentar em humanos no Brasil. Este parasito apresenta mecanismos de adaptação que podem ser guiados por suas proteases onde se ...

Recent insights on the medicinal chemistry of metal-based compounds: hints for the successful drug design

Hernandes, M. Z. et al. | Date Issued: 2010

Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins

Cavada, Benildo Sousa et al. | Date Issued: 2001

Ruthenium complexes endowed with potent anti-Trypanosoma cruzi activity: Synthesis, biological characterization and structure-activity relationships

Donnici, Claudio Luis et al. | Date Issued: 2009

Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.

Moreira, Diogo Rodrigo Magalhães et al. | Date Issued: 2012

Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents

Hernandes, Marcelo Zaldini et al. | Date Issued: 2010

Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi

Leite, Ana Cristina Lima et al. | Date Issued: 2006