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CORRELATIONS OF MUTATIONS IN KATG, OXYR-AHPC AND INHA GENES AND IN VITRO SUSCEPTIBILITY IN MYCOBACTERIUM TUBERCULOSIS CLINICAL STRAINS SEGREGATED BY SPOLIGOTYPE FAMILIES FROM TUBERCULOSIS PREVALENT COUNTRIES IN SOUTH AMERICA
Costa, Elis R. Dalla et al. | Date Issued: 2009
Author
Costa, Elis R. Dalla
Ribeiro, Marta O.
Silva, Márcia S. N.
Arnold, Liane S.
Rostirolla, Diana C.
Cafrune, Patricia I.
Espinoza, Roger C.
Palaci, Moises
Telles, Maria A.
Ritacco, Viviana
Suffys, Philip N.
Lopes, Maria L.
Campelo, Creuza L.
Miranda, Silvana S.
Kremer, Kristin
Silva, Pedro E. Almeida da
Fonseca, Leila de Souza
Ho, John L.
Kritski, Afrânio L.
Rossetti, Maria L. R.
Affilliation
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Rio de Janeiro, RJ, Brazil.
State Foundation for Production and Research in Health. Porto Alegre, RS, Brazil / Federal University of Rio de Janeiro. Tuberculosis Academic Program. Rio de Janeiro, RJ, Brazil.
State Foundation for Production and Research in Health. Porto Alegre, RS, Brazil.
State Foundation for Production and Research in Health. Porto Alegre, RS, Brazil / Luterana University of Brazil. Rio de Janeiro, RJ, Brazil.
State Foundation for Production and Research in Health. Porto Alegre, RS, Brazil.
State Foundation for Production and Research in Health. Porto Alegre, RS, Brazil.
State Foundation for Production and Research in Health. Porto Alegre, RS, Brazil / Federal University of Rio Grande do Sul. Porto Alegre, RS, Brazil.
Blufstein Clinic Laboratory. Lima, Peru.
Federal University of Espírito Santo. Vitória, ES, Brazil.
Adolfo Lutz Institute. São Paulo, SP, Brazil.
Instittuto Nacional Enfermedades Infecciosas. Servicio de Micobacterias. Argentina.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Rio de Janeiro, RJ, Brazil.
Evandro Chagas Institute. Manaus, AM, Brazil.
LACEN. Fortaleza, CE, Brazil.
Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
National Institute for Public Health and the Environment. Mycobacteria Reference Unit. Amsterdã, Netherlands.
Federal Foundation of Rio Grande. Porto Alegre, RS, Brazil.
Federal University of Rio de Janeiro. Tuberculosis Academic Program. Rio de Janeiro, RJ, Brazil.
Cornell University, Ithaca. New York, USA.
Federal University of Rio de Janeiro. Tuberculosis Academic Program. Rio de Janeiro, RJ, Brazil.
State Foundation for Production and Research in Health. Porto Alegre, RS, Brazil / Luterana University of Brazil. Rio de Janeiro, RJ, Brazil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brazil.
Abstract
Mutations associated with resistance to rifampin or streptomycin have been reported for W/Beijing and Latin American Mediterranean (LAM) strain families of Mycobacterium tuberculosis. A few studies with limited sample sizes have separately evaluated mutations in katG, ahpC and inhA genes that are associated with isoniazid (INH) resistance. Increasing prevalence of INH resistance, especially in high tuberculosis (TB) prevalent countries is worsening the burden of TB control programs, since similar transmission rates are noted for INH susceptible and resistant M. tuberculosis strains.
Keywords in Portuguese
Mycobacterium tuberculosis
Mutações
Genes katG, oxyR-ahpC e inhA
Linhagens clínicas
Amílias de espoligotipos
América do Sul
Tuberculose
 
Keywords
Mycobacterium tuberculosis
OxyR-ahpC and inhA genes
Mutations
Spoligotype families
Tuberculosis
South America
Clinical strains
 
Publisher
BioMed Central
Citation
DALLA COSTA, Elis R. et al. Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America. BMC Microbiology, v. 9, n. 39, p. 1-11, Feb. 2009.
DOI
10.1186/1471-2180-9-39
ISSN
1471-2180