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A POTENTIAL SARS-COV-2 VARIANT OF INTEREST (VOI) HARBORING MUTATION E484K IN THE SPIKE PROTEIN WAS IDENTIFIED WITHIN LINEAGE B.1.1.33 CIRCULATING IN BRAZIL (PREPRINT)
Betacoronavirus
Epidemias
Mutação
Brasil
Rede Genômica Fiocruz
GENOMAHCOV
https://www.arca.fiocruz.br/handle/icict/52621
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Abstract
The SARS-CoV-2 epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. Two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved within lineage B.1.1.28 and are rapidly spreading in Brazil. Lineage P.1 is considered a Variant of Concern (VOC) because of the presence of multiple mutations in the S protein (including K417T, E484K, N501Y), while lineage P.2 only harbors mutation S:E484K and is considered a Variant of Interest (VOI). Here we report the identification of a new SARS-CoV-2 VOI within lineage B.1.1.33 that also harbors mutation S:E484K and was detected in Brazil between November 2020 and February 2021. This VOI displayed four non-synonymous lineage-defining mutations (NSP3:A1711V, NSP6:F36L, S:E484K, and NS7b:E33A) and was designated as lineage N.9. The VOI N.9 probably emerged in August 2020 and has spread across different Brazilian states from the Southeast, South, North and Northeast regions.
Keywords in Portuguese
SARS-CoV-2Betacoronavirus
Epidemias
Mutação
Brasil
Rede Genômica Fiocruz
GENOMAHCOV
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